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Psychedelic · 295 Erowid reports

Syrian Rue

In brief

Peganum harmala seeds rich in harmala alkaloids (reversible MAOI). Barely psychedelic alone, mainly used to potentiate DMT (ayahuasca analogs). Dangerous MAOI interactions.

Tolerance

A (reversible) MAO inhibitor: the issue is not tolerance but interactions. Risk of hypertensive crisis and serotonin syndrome with tyramine, SSRIs and other serotonergics. Respect washout times.

Contraindicated combinations

It is an MAOI: many serious interactions. Contraindicated with SSRIs/SNRIs, other MAOIs, tramadol, DXM, stimulants (amphetamines, MDMA, cocaine) and tyramine-rich foods (aged cheeses, cured meats): serotonin syndrome or hypertensive crisis. Check every medication beforehand.

Major risks, not exhaustive; when in doubt, check a harm-reduction resource.

Duration

Route : oral · onset ~45 min · peak ~1 h 30 · duration ~6 h
02 h4 h6 hintensity

Indicative orders of magnitude; they vary with dose, route and individual.

La Honda notes

No La Honda note on this substance yet.

Erowid reports (295)

Sample of the 50 most recent out of 295. © Erowid Center.

Synthesis

Synthesis article to be written (phase 2): pharmacology, phenomenology, mechanisms, harm reduction, sources.