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Psychedelic · 295 Erowid reports
Syrian Rue
In brief
Peganum harmala seeds rich in harmala alkaloids (reversible MAOI). Barely psychedelic alone, mainly used to potentiate DMT (ayahuasca analogs). Dangerous MAOI interactions.
Tolerance
A (reversible) MAO inhibitor: the issue is not tolerance but interactions. Risk of hypertensive crisis and serotonin syndrome with tyramine, SSRIs and other serotonergics. Respect washout times.
Contraindicated combinations
It is an MAOI: many serious interactions. Contraindicated with SSRIs/SNRIs, other MAOIs, tramadol, DXM, stimulants (amphetamines, MDMA, cocaine) and tyramine-rich foods (aged cheeses, cured meats): serotonin syndrome or hypertensive crisis. Check every medication beforehand.
Major risks, not exhaustive; when in doubt, check a harm-reduction resource.
Duration
Indicative orders of magnitude; they vary with dose, route and individual.
La Honda notes
No La Honda note on this substance yet.
Erowid reports (295)
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Sample of the 50 most recent out of 295. © Erowid Center.
Synthesis article to be written (phase 2): pharmacology, phenomenology, mechanisms, harm reduction, sources.