DXM

In brief

A cough suppressant that turns dissociative at high doses (NMDA antagonist), in successive plateaus. Serotonergic risk, and danger from multi-ingredient syrups.

Tolerance

Tolerance sets in quickly with repeated use, pushing escalation. It inhibits CYP2D6 (so its own metabolism and that of other drugs); chronic use is linked to cognitive and, depending on the syrup, hepatic risks.

Contraindicated combinations

MAOIs: a dangerous combination (hyperthermia, serotonin syndrome). Avoid other serotonergics (SSRIs/SNRIs, MDMA, tramadol) and depressants (alcohol, opioids). Beware multi-ingredient syrups (paracetamol, antihistamines).

Major risks, not exhaustive; when in doubt, check a harm-reduction resource.

Duration

Route : oral · onset ~45 min · peak ~2 h · duration ~6 h

Indicative orders of magnitude; they vary with dose, route and individual.

La Honda notes

No La Honda note on this substance yet.

Erowid reports (552)

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Synthesis

Synthesis article to be written (phase 2): pharmacology, phenomenology, mechanisms, harm reduction, sources.