Diphenhydramine

In brief

An antihistamine that turns deliriant at high doses (anticholinergic), with realistic hallucinations, confusion and dysphoria. A seldom-sought, risky experience (cardiotoxic in overdose).

Tolerance

Tolerance is beside the point: the experience is dysphoric and the overdose risk is cardiotoxic. An anticholinergic, not to be repeated.

Contraindicated combinations

Do not combine with other anticholinergics (other antihistamines, some antidepressants, Datura): additive toxicity. Avoid depressants and stimulants. Cardiotoxic in overdose.

Major risks, not exhaustive; when in doubt, check a harm-reduction resource.

Duration

Route : oral · onset ~1 h 30 · peak ~3 h · duration ~9 h

Indicative orders of magnitude; they vary with dose, route and individual.

La Honda notes

No La Honda note on this substance yet.

Erowid reports (276)

· 2013
· 2013
· 2013
· 2013
· 2012
· 2012
· 2012
· 2011
· 2011
· 2011
· 2011
· 2011
· 2011
· 2011
· 2011
· 2010
· 2010
· 2010
· 2010
· 2010
· 2010
· 2010
· 2010
· 2009
· 2009
· 2009
· 2009
· 2009
· 2009
· 2009
· 2009
· 2009
· 2009
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008
· 2008

Synthesis

Synthesis article to be written (phase 2): pharmacology, phenomenology, mechanisms, harm reduction, sources.