Nitrous Oxide

In brief

A very short-acting dissociative gas (NMDA antagonist), euphoria and sound distortion for a few minutes. Hypoxia risk, and vitamin B12 depletion with repeated use (neuropathy).

Tolerance

Very brief acute tolerance within a session. The real risk of repeated use is vitamin B12 depletion (neuropathy, spinal cord damage), independent of tolerance.

Contraindicated combinations

Do not combine with alcohol or other depressants (benzodiazepines, opioids): hypoxia, loss of consciousness, falls. Always sit down. Repeated use depletes vitamin B12 (supplement it).

Major risks, not exhaustive; when in doubt, check a harm-reduction resource.

Duration

Route : inhaled · onset ~18 s · peak ~30 s · duration ~5 min

Indicative orders of magnitude; they vary with dose, route and individual.

La Honda notes

No La Honda note on this substance yet.

Erowid reports (309)

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Synthesis

Synthesis article to be written (phase 2): pharmacology, phenomenology, mechanisms, harm reduction, sources.