Breakthrough under N,N-DMT

The breakthrough under N,N-DMT refers to the crossing of a threshold beyond which the experience is no longer a mere intensification but a temporary substitution of the ordinary world by an autonomous phenomenological regime. The plate places it within a cautious explanatory frame: predictive coding, the REBUS model, the anarchic brain (Carhart-Harris and Friston, 2019). It maps the thresholds, bifurcations, and plausible mechanisms.

Neurochemical action

The sheet describes N,N-DMT as a tryptamine agonist around 5-HT2A receptors, with 5-HT1A, sigma-1, and TAAR1 involvement. The attributed effects: 5-HT2A for the loosening of the high layers of the default mode network (DMN); sigma-1 for integrative modulation, salience, and an unusual valence; 5-HT1A and TAAR1 for affective modulation and arousal. The result is a rapid disintegration of perceptual filters and of the internal model.

Bayesian predictive loop (REBUS)

The central frame remains that of explosive prediction error. Under N,N-DMT, priors and descending predictions collapse abruptly, internal signals (sensory and endogenous) flood the estimate, and the inference (the internal model) loses its coherence. The mechanism rests on the collapse of high-level predictions and the takeover by internal content. The plate calls this an explanatory candidate frame (REBUS model), useful but not ontological proof.

Functional consequences

The extreme reorganization of perception is detailed: appearance of autonomous spaces and worlds; intentional entities or presences; dissolution of the ego and rupture of the subject-object coupling; noetic quality (evidence, felt truth); ineffability, the difficulty of describing the experience in ordinary language.

Mapping the thresholds under N,N-DMT

The plate distinguishes six thresholds or alternative trajectories according to the scale of depth:

• Threshold 1, loosening of the DMN: intensified vision, vivid textures, but no rupture of the self.
• Threshold 2, plasticity of the real: dismantling of the ego, distorted perception, autonomous identity fissure (pre-breakthrough state).
• Threshold 3, allusive presences: silhouettes, gazes, fleeting communication, pre-breakthrough.
• Threshold 4, breakthrough with entities: another world, coherent and autonomous, near-certain entities (the ordinary becomes the anomaly).
• Threshold 5, unitive collapse: disappearance of entities and of the observer, dissolution of the self, ontological infinity, partial convergence with 5-MeO-DMT.

Typical phenomenological regimes

The sheet lists several regimes: entity encounters (autonomous presences, communication or interaction, lived as real); autonomous realities (coherent spaces, places of their own, the impression of an inhabited elsewhere); insight and noesis (a sense of evidence, of immediate understanding, felt truth); symbolic death and rebirth (dissolution, tipping, reconstruction of meaning); unity without an observer (in some trajectories, no more world, no more entities, no separate witness).

Neuroscientific data and result

The mentioned correlates: disintegration of cortical networks (DMN, ECN), increased cross-network integration; a massive rise in brain entropy (EEG and fMRI); EEG signatures of the breakthrough (Timmermann 2019 to 2023, entity or world at breakthrough). The overall result is described as the most radical phenomenological collapse, where the internal model of reality is temporarily suspended in favor of an autonomous regime. The plate notes that these perceived contents (entities, spaces, intelligences) remain an open problem.

Duration, tolerance, and precautions

The stated duration: vaped or smoked, onset 10 to 30 seconds, plateau 3 to 8 minutes, return 10 to 20 minutes, longer integration. Tolerance is described as low to moderate, cross-tolerant with other 5-HT2A agonists, with no marked MDMA-type tachyphylaxis. The sheet stresses precautions (an extremely intense experience, essential set and setting, psychotic vulnerability, integration), without offering medical advice. N,N-DMT is presented as present in many plants (Psychotria viridis, Mimosa hostilis, Acacia spp.) and as endogenous traces, not to be confused with 5-MeO-DMT.

Sources

• Carhart-Harris and Friston (2019), REBUS model and anarchic brain.
• Timmermann and colleagues, EEG signatures of the DMT breakthrough (2019, 2023).
• Strassman (2001), research on N,N-DMT and entities.
• Literature on predictive coding, brain entropy, and psychedelics.